Volume 27, Part 2

Combined Fluoxetine with Cognitive-Behavioral Therapy vs. Monotherapy in the Treatment of Adolescents with Major Depressive Disorder
How to best treat adolescents with severe depression has been a subject of widespread debate throughout the medical and mental health community. In this lesson, Dr. Vitiello considers the advantages and disadvantages of both pharmacotherapy and psychoanalysis as separate treatment modalities, as well as the efficacy of a combined approach. Read More

Neuroendocrine-Based Pharmacotherapy for Depression
The latest medical care for depression accounts for a wide range of biological factors that may influence an individual's response to treatment. Dr. Soares and Papakostas analyze the available research favoring the use of neuroendocrinologic compounds in the treatment of depression. Read More

Pharmacological Treatments for Bipolar Depression: Focus on Atypical Antipsychotics
Depression is known to be the most treatment-resistant aspect of bipolar disorder (BD), manifesting a need for efficacious pharmacologic therapy. In this lesson, Drs. Kemp, Muzina, Gao, and Calabrese illuminate the findings from trials of olanzapine, olanzapine-fluoxetine combination, and quetiapine in the management of acute BD, and those of olanzapine and aripiprazole on relapse prevention. Read More

Neurological Abnormalities in Schizophrenia
Neurological abnormalities (NAs), including hard signs, soft signs, and extrapyramidal side effects, are regularly detected in individuals with schizophrenia. Drs. Picchioni and Dazzan explore the relationship between NAs and schizophrenia, focusing on how best to assess these abnormalities and what relevance they may have to treating planning. Read More

Cognitive-Behavior Therapy for Schizophrenia
Cognitive-behavioral therapy (CBT) is not often considered the first course of treatment for the multiple, severe, and enduring problems that define schizophrenia. Yet Drs. Arjundas and Turkington provide a solid case for incorporating this therapy into the range of treatment alternatives with evidence for its effectiveness and structured tools to assist in its application. Read More

Update on Sexual Addictions
The authors provide a comprehensive overview of this often overlooked or misunderstood set of disorders that exist in the overlap between impulse-control disorders, addictive disorders, and the obsessive compulsive spectrum. This lesson offers concrete data to support its classification of particular disorders, including definitions, symptoms, comorbidities, assessment tools, and promising therapeutic and pharmacological treatment options. Read More